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Contraindications Known hypersensitivity reaction to Nifedipine. These responses have usually occurred during initial titration or at the time of subsequent upward dosage adjustment, generic nifedipine usa and may be more likely in patients on concomitant beta blockers. Co-administration of nifedipine with grapefruit juice results in up to 2-fold increase in AUC and Cmax, due to inhibition of CYP3A4 related first-pass metabolism. Cardiovascular Considerations:Considerable attention has been directed to potential increases in mortality and morbidity when short-acting nifedipine is used in treating hypertension.
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